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Tumor Secreted grp170 as a Cancer Vaccine
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Grp170 is a major molecular chaperone/stress protein §resident in the ER. It is distantly related in §sequence to both hsp110 and hsp70 families. Although §most chaperones are intracellular proteins they can §be modified into secretory proteins. Chaperones §secreted into the tumor microenvironment can recruit §professional APCs and promote antigen presentation §and priming of T-lymphocytes. This book describes an §approach to target grp170 to the tumor §microenvironment, which results in tumor rejection §mediated by an adaptive immune response that is CD8+ §dependent and accompanied by an enhanced cellular §immune response against a tumor-specific antigen. §Furthermore, the secreted grp170 is shown to deliver §full-length tumor antigens to the tumor §microenvironment. This approach has the potential §of being exploited clinically as a cancer-specific §vaccine in tumors of various histological origins.
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