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In this book, we present a novel framework of high-tech modern medicine. Patients going through major high-tech medical interventions, e.g. Advanced Heart Failure (AdHF) patients undergoing left ventricular assist device (LVAD) implantation and heart transplantation, must integrate scientific and technological advances into personal life, including strong emotional experiences unthinkable thirty years ago, novel to themselves and their caregivers and unknown to physicians. Our book provides a theoretical framework for the patient-centered vision to "heal humankind by improving health, alleviating suffering and delivering acts of kindness, one person at a time". In the book, we develop the theoretical as well as practical concept of the "RelationalAct (RA)" as core concept to engage and participate in modern medicine.