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This book stands at the heart of the reciprocal interactions between pain, emotion and cognition. International experts report their knowledge, clinical experience and the most recent literature on the complex tri-directional relationships of between these three domains. Clinical, psychological, behavioral and neuroimaging approaches converge towards the patient suffering from pain, cognitive impairment or emotional distress. Beyond the pathophysiological aspects of pain, difficulties encountered with patients are analyzed and strategies are proposed to optimize treatment, doctor-patient relationships, and the well-being of patients.