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Fibrin sealant is used for numerous indications in gynecology, especially for the McIndoe Operation and Cohn biopsy, the Marshall-Marchetti-Krantz-Hirsch-Stoll-Operation, urethrocysopexy, or in vitro fertilization for embryo transfer. The use of fibrin sealant in urology has also been extended, especially in operations of the spermatic cord, reconstruction of the urethra and closing of nephrotomies. The use of fibrin glue in gynecological and urological surgery is an established procedure. An international team of authors offers an update review including the most recent possibilities for applying fibrin sealants, e.g. in reconstructive urological surgery.