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Dynamical mechanism of action of antidepressant drugs
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All existing antidepressant drugs are characterized by relatively long delay (two-eight weeks) between the beginning of the medication and onset of therapeutic effect of the treatment. One of the goals of psycho-pharmacological research is to create novel treatment strategies with rapid onset of the beneficial effect. The research project described in this book aimed to assess, using an animal model of depression,dynamical changes in brain neuro-chemistry and behavior following the administration of different antidepressant drugs. The main intend was to understand the neuronal mechanism of early onset of behavioral effects of antidepressant treatment. The research was focused on reward system and on serotonin-dopamine interactions in the nucleus accumbens. This book dedicated to the memory of author's devoted teacher and his primary scientific mentor, Dr. Michael E. Newman.
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