DNA Damage and Repair

Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.DNA Damage and Repair offers a critical, cutting-edge review of all major aspects of DNA repair in a wide variety of organisms, including every important model system. Volume II: DNA Repair in Higher Eukaryotes focuses mammalian systems and human genetic disease and cancer, emphasizing the significant progress that has been made in the past five years. Written by award-winning researchers at the forefront of their fields, each chapter has undergone a rigorous peer-review cycle to ensure definitive and comprehensive treatment of its topic. Extensive up-to-date references, along with clear figures illustrating complex relationships between DNA repair and other DNA dynamic processes and cell functions, bring this volume to the active frontiers of research. Major topics include UV and X-ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. A complementary volume, Volume I: DNA Repair in Prokaryotes and Lower Eukaryotes , focuses on DNA damage and repair in prokaryotic and model eukaryotic systems. §This major new treatise provides the reader with up-to-date critical surveys of every important area of research on DNA damage and the repair mechanisms in each major system currently under investigation. Authoritative and timely, DNA Damage and Repair is certain to become the new standard reference and resource in the field.